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Nanomedicine: Nanotechnology, Biology and Medicine
Vol. 11 (6), 2015, Pages: 1531–1549

Synchrotron radiation techniques for nanotoxicology

Yu-Feng Li, PhD, Jiating Zhao, PhD, Ying Qu, PhD, Yuxi Gao, PhD, Zhenghang Guo, Zuoliang Liu, PhD, Yuliang Zhao, PhD, Chunying Chen, PhD

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, and Laboratory of Metallomics and Nanometallomics, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.

Abstract

Nanotoxicology studies the interactions of engineered nanomaterials with biological systems. Traditional in vitro and in vivo toxicological assays have been successfully employed. However, the toxicological mechanisms of nanoparticles might not be the same as those incurred in traditional molecular toxicology. Furthermore, how to realize in situ and real time measurements especially in the biological microenvironment is still a challenge. Synchrotron radiation, which is highly polarized and tunable, has been proved to play an indispensible role for nanotoxicology studies. In this review, the role of synchrotron radiation techniques is summarized in screening physicochemical characteristics, in vitro and in vivo behaviors, and ecotoxicological effects of engineered nanomaterials.

Graphical abstract

Keywords: Synchrotron radiation; Nanotoxicology; In vitro; In vivo; Ecotoxicology.

 
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