Home About us MoEF Contact us Sitemap Tamil Website  
About Envis
Whats New
Research on Microbes
Microbiology Experts
Online Submission
Access Statistics

Site Visitors

blog tracking

Phytochemistry Letters
Volume 43, 2021, Pages 45-52

Three new dihydroisocoumarin glycosides with antimicrobial activities from Scorzonera aucheriana

Ishak Erika, Nurettin Yaylia, Kamil Coskunçelebib, Serdar Makbulc, Sengül Alpay Karaogluc

Department of Pharmacognosy, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey.


Three new dihydroisocoumarin glycosides (iso-scorzopygmaecoside, scorzoaucherioside I, and scorzoaucherioside II) together with five known compounds (scorzopygmaecoside, scorzocreticoside II, 3,5-O-dicaffeoyl-epi-quinic acid, 3,5-O-dicaffeoylquinic acid, and 3,4-dihydroxyphenyl caffeate) were isolated from the aerial parts of the Scorzonera aucheriana collected from Sivas province in Turkey. The isolated compounds' structures were elucidated based on NMR (1H, 13C/APT, COSY, HMBC, HSQC, and TOCSY), UV, FT-IR, and LC-QTOF-MS data. These compounds have been isolated for the first time from S. aucheriana. An antimicrobial assay against ten microorganisms was applied to all isolated compounds. Iso-scorzopygmaecoside, scorzoaucherioside I, and 3,4-dihydroxyphenyl caffeate showed notable anti-pseudomonal activity. Iso-scorzopygmaecoside and scorzoaucherioside II exhibited strong activity against Mycobacterium smegmatis with MIC values of 25.6 μg/mL and 21.2 μg/mL, respectively.

Keywords: Scorzonera aucheriana, Dihydroisocoumarins, Isolation, Antimicrobial activity.

Copyright © 2005 ENVIS Centre ! All rights reserved
This site is optimized for 1024 x 768 screen resolution