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Journal of Ethnopharmacology
Vol. 156, 2014, Pages: 228234

Isolation and characterization of antimicrobial compounds from Terminalia phanerophlebia Engl. & Diels leaf extracts

B. Madikizela, M.A. Aderogba, J.F. Finnie, J. Van Staden

Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal, Scottsville 3209, Private Bag X01,Pietermaritzburg, South Africa.


The emergence of drug resistant-tuberculosis and other pathogenic diseases over the past decades, constitutes a serious threat to human health worldwide. According to a 2012 report by the World Health Organization (WHO), South Africa, China, India and Russia are the countries with the highest prevalence of Multi-Drug Resistant tuberculosis (MDR-tuberculosis) as they represented 60% of the total. Several reports have documented antimycobacterial properties of Terminalia species but only a few species from this genus have been explored for their antimycobacterial constituents. The crude extracts of Terminalia phanerophlebia showed good antimicrobial activities in our previous study against two Mycobacterium as well as two other bacterial strains responsible for opportunistic infections related to respiratory ailments. This paper studies the isolation of compounds responsible for such activities and to isolate compounds responsible for antimicrobial activities from the crude extracts of Terminalia phanerophlebia leaves.

Keywords: Antimicrobial; Methyl gallate; Phenylpropanoid glycoside; Terminalia phanerophlebia; Tuberculosis.

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