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World Journal of Microbiology and Biotechnology
Vol. 31, No. 3, 2015; Pages: 445-451

Asparagopsis armata and Sphaerococcus coronopifolius as a natural source of antimicrobial compounds

Susete Pinteus, Celso Alves, Hugo Monteiro, Ernesto Araújo, André Horta, Rui Pedrosa

Marine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641, Peniche, Portugal.


Methanol, n-hexane and dichloromethane extracts of twelve marine macro-algae (Rhodophyta,Chlorophyta and Heterokontophyta divisions) from Peniche coast (Portugal) were evaluated for their antibacterial and antifungal activity. The antibacterial activity was evaluated by disc diffusion method against Bacillus subtilis (gram positive bacteria) and Escherichia coli (gram negative bacteria). Saccharomyces cerevisiae was used as a model for the antifungal activity by evaluating the growth inhibitory activity of the extracts. The high antibacterial activity was obtained by theAsparagopsis armata methanolic extract (10 mm–0.1 mg/disc), followed by the Sphaerococcus coronopifolius n-hexane extract (8 mm–0.1 mg/disc), and the Asparagopsis armata dichloromethane extract (12 mm–0.3 mg/disc) against Bacillus subtilis. There were no positive results against Escherichia coliSphaerococcus coronopifolius revealed high antifungal potential for n-hexane (IC50 = 40.2 µg/ml), dichloromethane (IC50 = 78.9 µg/ml) and methanolic (IC50 = 55.18 µg/ml) extracts against Saccharomyces cerevisiae growth. The antifungal potency of the Sphaerococcus coronopifolius extracts was similar with the standard amphotericin B. Asparagopsis armata and Sphaerococcus coronopifolius reveal to be interesting sources of natural compounds with antimicrobial properties.

Keywords: Marine algae, Antibacterial activity, Antifungal activity, Seaweeds, Marine natural compounds, Natural antibiotics.

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